WHMCS really rocks for Billing/Client Management. For Helpdesk Kayako is good with rapidly developed applications.
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WHMcs is by far the best for billing and client management. I feel you could operate most of your company using WHMcs. They have a solid ticket system feature that can be used for billing, tech support or anything else. If you want to keep WHMcs just for billing and have another application for tech support / help desk Kayako would be your best choice. Best of luck to you!
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