fastclick.com is the best, in my opinion. I use them on all of my high-traffic sites with great revenue and quick pay checks
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Fastclick www.tribalfusion.com www.burstmedia.com
are all pay per impresion, why do you want them to be targeted? you get paid for the impressions and not the clicks. so non targeted are better as you loose less visitors.
Fastclick is pretty aweful with low rates and crap ads (flashing, jittering, annoying stuff).
saghir69... you want it targetted as they pay more... even ads from the same company may pay more when targetted for you by Tribal Fusion or Burst... I have some now like that... "run of network" versions may pay $2 cpm... an ad from the same company, but targetted for me, may pay $6 cpm. And other ads that only show in targetted campaigns and may be $4-$8 cpm from these companies.