Originally Posted by cspence
I know nginx does not support htaccess, do you have to manually edit configuration files to configure permalinks and other htaccess related things under Wordpress? I also use W3 Total Cache, which I know now supports nginx, but I am not sure how much configuration you have to do manually.
W3 Total Cache works well with nginx. It can generate rewrite rules for nginx and you can include the configuration file generated by W3 Total Cache in your nginx configuration, so you don't have to set up these rules manually (or translate the Apache rules).
Over all, you'd have to come up with a suitable nginx configuration initially, when you make the transition, but later on, usually you wouldn't have to modify it anymore.
EDIT: That's assuming that you use nginx alone, not just as a reverse proxy for Apache.