We use fantastico becuase that's what we started out with...but softaculas is looking really great because they are cheaper and I think they provide more scripts. But I don't know if their service quality and their whm software is better or not.
If you are just starting out you want to make sure you have everything laid out before you begin as a few aspects might cost some money or require you to sideline capital.
First your server and control panel
Second your Billing / automation software
Third Independent monitoring station(s)
Forth Credit card processors (some require you to put 500 dollars or more into your account, or have a limit on what your checking account can go below).
If you spend some time around the forum read and doing a lot of it you've be able to put a business plan together.
Between these two, I would certainly look at Softaculous.
I've used Fantastico in the past and found it to be quite bloated - I am not sure how much of that has changed over the years, but looking at it again briefly it still seems sub-par compared to others.
An alternative to Softaculous is Installatron, which I'd also rank above Fantastico.
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Softaculous knew they would have to make a bigger and better Fantastico and they did.
We're stuck with Fantastico on our old servers but all our new ones are deploying with Softaculous.
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Softaculous without a doubt....Fantastico is like a throwback to ten years ago.
One thing everyone including the OP might want to consider is if you every transfer to a different server in the future or transfer a new client to your server and they are used to using fantastico, it's best to stick to the same one they have had in the past. That's why we still use fantastico because we know it will work 100% and it will be familiar to new and old clients regardless. I'd like to someday have both fantastico and softaculous, but it's not necessary now.
fantastico or softaculous
I would tell you that ofcourse is softaculous. Why?
because fantastico only provide 50 something of CMS but softeculous provide you more than 100 kinds of CMS. Beside that softaculous CMS are more update compare to fantastico. Lot of software in Fantastico are not update.
So please go with softaculous, you paid for it so why not use the latest one unless you feel fantastico is more friendly and you use to it.