It really depends on what you are planning to host. If it is low traffic website apache will be enough, but if you get quite a lot unique visitors on your site it is better to use lightspeed. It will decrease cpu and memory usage.
Personally, I prefer using Apache for everyday jobs. But, that's 15+ years worth of experience lending to a nice, comfortable bias of familiarity
I do use litespeed/lighttpd when I have a setup with a ton of php/etc calls, however.
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You use the best web server for the job. You're appealing to the masses you need Apache compatibility. So your choices are Apache or Litespeed nothing else will work. So it's a matter of evaluating if it's worth the cost of Litespeed or can you do what you want with Apache with various optimizations and tweaks and everything.
If you're running web servers where it's for a single website. You don't need to worry about the apache compatibility. You can run nginx and make your own rewrites for nginx.
So really it's about the web server for the job at hand.
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I will say is that Litespeed is very marketable. Even for a visitor that doesn't know what Litespeed is their logo and the name itself works quite well
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