One of our clients require an easy to use eCommerce script. I have reviewed a number of eCommerce scripts including osCommerce, Zen Cart, X Cart, etc, but I did not find it particularly design appealing or user friendly.

Does the WHT Community have suggestions of scripts (willing to pay) that is able to create nice look eCommerce websites, and with a clean and easy to use back-end administrative panel? It would be a bonus if its Web 2.0.

Any suggestions?

set up oscommerce, buy a template from templatemonster (osc template) and install it. there are hundreds of templates for osc there of all sorts.

http://www.satchmoproject.com/ ???

http://www.satchmoproject.com/ ???

As far I know it is Python based project.
It is not based on PHP.

joomla + virtue mart is a good choice.