Anyone have any comments the domain hostspire.com?

espire, enspire - yup I like it :)

Better than many I've seen in a while to. But I think it's best for you to develop it yourself.

Its good. Its not excatly what I'd go for but its a decent domain and if you are thinking of developing it I give you the thumbs up. :)

spire: spiral. Not very well known word.
ire: anger, wrath. Well known and quite negative.

I'd pass.

Reminds me of the word "expire". That's what I think of after trying to figure out the sentence..."hosts pire"...what's "pire"? "PYRE", a funeral pyre? Then I realize ah, "host spire" but the overal impression is expire, fire, death and ashes, etc.

Be creative. There are many good domain names better than yours