Can I run plesk on windows to manage a remote mail server on another machines. Then multiple plesk boxes can use the same mail server.

Is that possible? If so how and where can I get more info.

I've been looking at this as well, and it looks like it is kind of difficult. You'd need Plesk Expand, which is unix only at this time, and all the documentation is a little vague exactly how well it works.

I had talked with Plesk support some and, basically, it doesn't really have built in support for a multi-server environment, and Plesk Expand is kind of weak on its Windows support.