Anyone updated glibc on a running box?

I need to update glibc from 2.2.2 > 2.2.4 as part of a kernel upgrade on my RH Linux/Ensim box but as I don't have access to the system in single user mode I have to do the update (install a couple of .rpm files) in full multiuser mode ... and I seem to remember doing that causes all sorts of hassle.

Anyone with experience doing this?

As long as the updates are official updates, I don't think that will cause a problem. I haven't experienced any major problem of updating glibc before.

Warning, make sure the files you download are not corrupted in any way. If you mess up the glibc install NOTHING on your system will work and you won't be able to reboot either. Only commands I know that'll work after glibc dies is "echo" and "cd".

Package management (like RPM) has checksums to avoid just that. But it always a good idea to double check everything.